The RealSense 400 Series cameras can be made to work with any flavor of Linux.
https://github.com/IntelRealSense/librealsense/issues/1132#issuecomment-363572666
In general though, Ubuntu is the most proven type of Linux to work well with RealSense and with Up Boards.
The link below discusses using a D415 with Up Board.
https://forums.intel.com/s/question/0D50P0000490XyySAE/aaeon-up-board-setup-with-2x-intel-realsense-depth-camera-d415
In the final comment of that discussion, the user - who was trying to run multiple D415 cameras on the board - says "I did a few tests and I confirm that a Up Squared board handles two D415 without difficulties".
